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A total number of 945 and 746 different proteins from body and headfoot samples respectively were identified over all time points studied (confidence threshold >?95%); of these, 452 proteins were common to both samples (Fig.?1A). Of all the proteins identified, only those whose credible interval (from iQuantitator analysis) was above or below 1 and whose log2 fold-change was >?0.6 or buy OSI-906 investigation. A total of 108 significantly differentially expressed proteins were found in the body samples, whereas only 43 proteins were differentially expressed in the headfoot of the infected snails (Fig.?1B). A comprehensive report was also generated with the iQuantitator software (Supplementary Files 1�C4 in [37]). A GO-enrichment analysis of significantly differentially expressed proteins from the body and the headfoot of infected snails was performed using Blast2GO [35]. The analysis revealed significant enrichment find more of the GO terms ��binding�� (13.2% and 14.4% in body and headfoot, respectively), ��catalytic activity�� (11.4% and 12.3%) and ��protein binding�� (8.3% and 9.8%) within ��molecular function�� (Fig.?2A) and ��single-organism cellular process�� (9.3% and 8%), ��regulation of biological process�� (8.7% and 8%), ��primary metabolic process�� (8.1% and 9.3%) and ��organic substance metabolic process�� (8.1% and 9.3%) within ��biological process�� (Fig.?2B). No significant differences were observed between enriched GO terms from flupentixol the body and headfoot of infected snails. Significantly differentially expressed proteins from the headfoot of infected snails were grouped into 8 GO annotation categories and plotted in a clustered heatmap (Fig.?3). Clustering was performed using Euclidean distances and dendrograms were reordered based on mean values. Proteins assigned to peptidase activity, and oxidoreductases (with the exception of 15-hydroxyprostaglandin dehydrogenase) together with proteins with a catalytic domain were significantly downregulated after infection with O. viverrini. Conversely, proteins involved in motor activity and structural proteins were upregulated in the headfoot of infected snails among the experiment ( Fig.?3). Significantly dysregulated proteins from the bodies of infected snails were grouped into 10 GO annotation categories and plotted in a clustered heatmap (Fig.?4). Clustering was also performed using Euclidean distances and dendrograms were reordered based on mean values. The majority of differentially expressed proteins were identified at 28�C56?dpi, and similar numbers of up- and downregulated proteins were detected.