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12 Preventable adverse events were determined applying Schumock questionnaire.13 All patients entered the study were classified to two different groups: Patients who developed at least one ADR (ADR patients) and patients who never experienced an ADR (Non-ADR patients). These two groups of patients were compared in sex and age by using chi-square test. Also the duration of drug usage were compared in ADR and Non-ADR patients using t-test. For assessing the relationship between frequencies of ADRs occurred and the number of drugs used, Pearson analysis was performed. RESULTS A total of 518 patients, 212 men and 306 women, using cardiovascular medications entered the study. One hundred and five patients (20.3%) Crizotinib purchase including 34 men and 71 women experienced at least one ADR. There were 54 patients (51.4%) who developed more than one ADR. Two ADRs in 26 patients (24.8%), three ADRs in 21 (20%), four ADRs in 5 (4.8%), five ADRs in 1 (1%) and six ADRs in 1 (1%) patient was reported. Detected ADRs were mostly observed in the age group of 51-60 (Table 1). Calcium channel blockers and potassium sparing diuretics had the highest and lowest rate of ADRs respectively (Table 2). The highest rate of ADRs was recorded to be induced by Diltiazem (23.5%) and the lowest rate was related to Atenolol (3%). Central learn more nervous system and Gastrointestinal system disorders were the most frequent system-organ classes affected with ADRs. (Table 3) Headache, vertigo, weakness, nausea and vomiting were the most frequent reactions. (Table 4) Among ADRs evaluated, 1.1% was recognized as serious and 1.9% as preventable ADRs. Causality assessment of ADRs revealed that the most frequent ADRs (75.9%) were recognized to be certain, followed by 19.2% as possible, 3% as probable and 1.9% as unlikely. Withdrawal of suspected drug was necessary in 22.2% of ADR patients, the treatment was continued in 65.6%, the dosage was decreased in 6.3%, the treatment was continued by alternate drug in 3.7% and 2.2% of the patients went through symptomatic therapy. The most common outcome UGT1A7 of ADRs was ��not yet recovered��, which refers to the ADRs not completely recovered by the end of the study (Table 5). Table 1 Number of ADRs in different age groups. Table 2 Number of ADRs induced by different subclasses of cardiovascular agents. Table 3 Different system-organ classes affected by ADRs. Table 4 Different ADRs induced by cardiovascular agents. Table 5 Outcome of detected ADRs induced by cardiovascular agents. The result of chi-squared test for comparing sex between ADR and Non-ADR patients showed that women significantly developed more ADRs in this study (chi square = 3.978, P