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The activity of these preparations was also tested in an assay of histamine release from human basophils in whole blood. Compared with mice challenged with control CPE, mice challenged with CPE w/o 20?kD experienced reduced symptoms (P?learn more release assay corroborated these findings (P?Succimer improve clinical interpretation of SPT results for inhalant allergens by providing quantitative decision points. The GA2LEN SPT study with 3068 valid data sets was used to investigate the relationship between SPT results and patient-reported clinical relevance for each of the 18 inhalant allergens as well as SPT wheal size and physician-diagnosed allergy (rhinitis, asthma, atopic dermatitis, food allergy). The effects of age, gender, and geographical area on SPT results were assessed. For each allergen, the wheal size in mm with an 80% positive predictive value (PPV) for being clinically relevant RSL 3 was calculated. Depending on the allergen, from 40% (blatella) to 87�C89% (grass, mites) of the positive SPT reactions (wheal size?��?3?mm) were associated with patient-reported clinical symptoms when exposed to the respective allergen. The risk of allergic symptoms increased significantly with larger wheal sizes for 17 of the 18 allergens tested. Children with positive SPT reactions had a smaller risk of sensitizations being clinically relevant compared with adults. The 80% PPV varied from 3 to 10?mm depending on the allergen. These ��reading keys�� for 18 inhalant allergens can help interpret SPT results with respect to their clinical significance. A SPT form with the standard allergens including mm decision points for each allergen is offered for clinical use. ""An association between asthma and antibiotic usage has been demonstrated, and the issue of reverse causation and confounding by indication is much debated.