Getting A PDGFRB? Take A Look At These Suggestions

These include hemogram, renal function test (RFT), liver function test (LFT), random selleck chemicals blood sugar (RBS), serum electrolyte (SE), serology for human immunodeficiency virus (HIV) and hepatitis B surface antigen (HBsAg), chest X-ray (CXR), intravenous pyelography (IVP), barium enema (BE), contrast-enhanced computed tomography (CECT), contrast-enhanced magnetic resonance imaging (CE-MRI), biopsy of cervical lesion, creatinine clearance test (CCT), renal scan, electrocardiograph (ECG), echocardiography (ECHO), multi-gated acquisition scan (MUGA), bone scan, fused positron-emission tomography/computed tomography (PET-CT), audiometry, colposcopy, cystoscopy and sigmoidoscopy. Prescriptions for other investigations depend upon pre-existing co-morbid conditions. Routine performance of hemogram, biochemical investigation and cervical biopsy cannot be over-emphasized at this stage of discussion. Cervical cancer is routinely staged by the FIGO staging system. Staging is based on clinical pelvic examination, colposcopy, histopathology, CXR, IVP, cystoscopy and sigmoidoscopy. Imaging and surgical staging are not included in the FIGO staging system as these investigations are not available universally, although FIGO recommends documentation of these findings [24]. Hemogram and biochemistry have to be prescribed both at baseline, weekly, and before administering chemotherapy. PLX4032 Biopsy of the cervical lesion is the basis for diagnosis of cancer; some centers may nevertheless start anticancer therapy based on the findings of a clinical examination. Biopsy of cervical lesions should be insisted upon every time to avoid exposing the patient to the toxicity of anticancer therapy without any benefit. CXR, IVP, BE, renal scan, bone scan, cystoscopy, sigmoidoscopy and audiometry may be reserved for patients with specific symptoms, as routine investigation may yield positive findings in PDGFRB expectancy. CCT and renal scan, in addition to detecting a non-functional kidney due to cervical cancer, estimates glomerular filtration rate and subsequent risk of renal failure. However, serum creatinine is the gold standard for detecting renal failure, and obsolete CCT and costly renal scan may not be available in all the centers. Cisplatin is cardiotoxic when it is part of a multi-drug chemotherapy regimen, and it may not be appropriate to get ECG, ECHO, or MUGA when planning single-agent weekly CDDP in patients