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The enzymes are baited by carbazolyl-moieties attached to nanoparticles through a click transformation. The single-step procedure FRAX597 solubility dmso for attracting the enzymes to the particles is capable of concentrating the protein from raw lysate and sequestering all required components of the protein to maintain bioactivity. For more information, please read the Full Paper ��Substrate-Baited Nanoparticles: A Catch and Release Strategy for Enzyme Recognition and Harvesting�� by S. H. Foulger, and co-workers, beginning on page 2083. ""The cover picture illustrates a new approach to biomolecular sensing, a nanoelectronic-enzyme linked immunosorbent assay (ne-ELISA). The approach combines the power of a sandwich ELISA �C antibody/antigen OPHN1 selective binding and enzymatic conversion �C with electronic detection. The illustration depicts a captured antibody (red), a captured protein (white), and a reporter antibody complex (blue) on a semiconductor nanowire (turquoise). When activated, the reporter complex releases ions, causing a pH change (yellow) in the local aqueous environment, which is detected by the nanowire. Nanowire-detection approaches have an inherent limitation for detection in physiologic fluids due to ionic screening. The ne-ELISA approach circumvents this, enabling wide applicability for biomolecule detection in physiologic fluids, as well as decreasing the detection limits by many orders of magnitude. For more information, please read the Full Paper ��A Nanoelectronic Enzyme-Linked Immunosorbent Assay (ne-ELISA) for Detection of Proteins in Physiological Solutions�� by M. Reed, T. AZD2014 M. Fahmy, et al., beginning on page 232. ""The cover image shows fluorescence images of single immobilized double-stranded oligonucleotides. With photophysical and -chemical properties of fluorophores being the key to breaking the diffraction resolution barrier, the development of far-field fluorescence nanoscopy depends crucially on improved fluorescent probes. Stimulated emission depletion (STED) microscopy is combined with fluorophore stabilization through a reducing and oxidizing system (ROXS), and a significant improvement of photostability is demonstrated. This improvement can be exploited either for repetitive measurements necessary for 3D or dynamic STED imaging, or for maximizing its resolution. A lateral resolution