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The patient must buy-in to the regimen in order for it to be effective. Even the best treatment will not work if the patient is not willing to take it, stops taking it, or does not take it as instructed. One study administered a validated questionnaire to patients with type 2 diabetes in an outpatient clinic in Jordan. This included a self-reported medication adherence Megestrol Acetate scale (Morisky Scale), diabetes knowledge questionnaire (ADKnowl Questionnaire), and health-related quality of life (HRQoL) scale (EQ-5D Questionnaire). Patients were about nine times less likely to adhere to diabetes medications if they received more than one dose of medication per day, and the odds of adherence was inversely related to the number of medications prescribed; therefore, simplifying regimens, like using an FDC, can be beneficial.23 Side effects are a major factor that can affect adherence.23 While side effects are not benign, as discussed previously, the canagliflozin metformin combination was generally well tolerated in the Phase III study of canagliflozin vs placebo and sitagliptin in patients on background metformin with slightly less serious adverse events reported selleck in the canagliflozin groups (100 mg and 300 mg) compared to the combination with sitagliptin (4.1%, 3.3%, and 4.9%, respectively).20 There are also several side effects that may be advantageous for patients. Weight loss, reduced blood pressure, and increased HDL-cholesterol are associated with the canagliflozin and metformin combination.20 With the numerous diabetes medications that are associated with weight gain, patients already struggling with obesity may find this discouraging as it can make it more difficult for them to meet their weight loss goals. The combination SB431542 datasheet of a weight neutral medication, metformin, and a medication that has the potential for weight loss, canagliflozin, may appeal to these patients specifically.17 Hypoglycemia, another side effect of many diabetes medications, has the potential to affect many aspects of patients�� lives such as quality of life, work productivity, and medication adherence. One study assessed hypoglycemia as related to the patient��s perspective. Out of 6,065 patients treated with oral or injectable agents for diabetes, 56% of participants self-reported hypoglycemia, and of those, 29% experienced hypoglycemia recently. Of the patients who reported recent hypoglycemia, 60.9% had a low or medium adherence score, while only 39.1% had a high adherence score (based on Morisky Scale). More patients on diabetes medications with recent hypoglycemia reported interference with social activities in the previous 4 weeks compared to patients who never had hypoglycemia. A greater percentage of patients were absent from work in the recent hypoglycemia group compared to the group who never had hypoglycemia (7.6% vs 3.5%, P