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0001 for all age groups). In each age group, the median PFS and the median TTP were also consistently higher with lenalidomide/dexamethasone than with dexamethasone alone (Pselleck products Overall, these findings from the age-specific subanalysis were consistent with those from the overall MM-009 and MM-010 study populations. Indeed, international guidelines state that lenalidomide/dexamethasone is an appropriate treatment option for patients with RRMM, regardless of age [21]. In current daily clinical practice, a reduced dose of lenalidomide is often used for RRMM. According to a recent study from the Greek Myeloma Study Group, the initial Histone demethylase dose of lenalidomide was higher in patients aged find more although starting doses of lenalidomide and dexamethasone in the retrospective analysis of 110 patients with RRMM in Korea were based on MFDS recommendations, the majority of patients started on lenalidomide 25 mg on days 1-21 (84.5%) and dexamethasone 160 mg per cycle (61.8%) [17]. The lower dexamethasone dose and schedule (40 mg/day on days 1, 8, 15, and 22 of a 28-day cycle) were based on data from the US Eastern Cooperative Oncology Group (ECOG) E4A03 trial conducted in 445 patients with newly diagnosed MM [38]. In this study, lenalidomide/low-dose dexamethasone was associated with significantly better short-term OS (96% [95% CI, 94-99] vs. 87% [95% CI, 82-92], P=0.0002, at 1 year) and lower toxicity (grade 3 or worse: 35% vs. 52% of patients, P=0.