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Time-updated Cox regression models were conducted to examine predictors of HCV incidence. Findings? The proportion of IDUs reporting PO injection increased from 21% to 75% between 2004 and 2009 (P?ALK hazard ratio (AHR): 1.87; 95%CI:1.16, 3.03]. An effect modification was also found: PO injectors who did not inject heroin were more likely to become infected (AHR: 2.88; 95%CI: 1.52, 5.45) whereas no association was found for participants using both drugs (AHR: 1.19; 95% CI: 0.61, 2.30). Other independent predictors of HCV incidence were: cocaine injection, recent incarceration and >30 injections per month. Conclusions? Prescription opioid injectors who do not inject heroin are at greater risk for HCV seroconversion than are those injecting both heroin and prescription opioids. Important differences in age, behaviour and social context suggest a need for targeted outreach strategies to this population. ""To determine pre- and post-dosing effects of prenatal methadone compared to buprenorphine on fetal wellbeing. A secondary analysis of data derived from the Maternal Opioid Treatment: Human LX4211 price Experimental Research (MOTHER) study, a double-blind, double-dummy, randomized clinical trial. www.selleckchem.com/products/ory-1001-rg-6016.html Six United States sites and one European site that provided comprehensive opioid-dependence treatment to pregnant women. Eighty-one of the 131 opioid-dependent pregnant women completing the MOTHER clinical trial, assessed between 31 and 33 weeks of gestation. Two fetal assessments were conducted, once before and once after study medication dosing. Measures included mean fetal heart rate (FHR), number of FHR accelerations, FHR reactivity in the fetal non-stress test (NST) and biophysical profile (BPP) score. Significant group differences were found for number of FHR accelerations, non-reactive NST and BPP scores (all Ps?