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Conclusion This is the first study to examine the use of statins in those at high risk of CVD in a nationally representative sample of adults aged 50�C64?years in Ireland. Despite strong evidence and clinical guidelines supporting the use of statins for secondary prevention of CVD, this study reveals a gap between guidelines and clinical practice in this group. An immediate policy response is required to strengthen secondary prevention for those with existing CVD. For the remainder of the population without evidence of CVD, population strategies for primary prevention are required as well as opportunistic risk assessment to identify those at high risk of future CVD in order to establish best practice in primary prevention. Acknowledgments The authors are grateful to all of the TILDA respondents who gave generously of their time in participating in this study. They also acknowledge the contribution of our CYTH4 collaborator Dr Angie Brown at the Irish Heart Foundation and Dr Marie Therese Cooney for providing assistance with the Stata code for SCORE. Footnotes Contributors: CM was the lead researcher and was involved in the design, implementation, analysis and reporting of the study. ES, TF, KB, IG and RAK provided substantial contributions to the conception and design of the work, and all have read and approved the final manuscript. Funding: This work was supported by the Irish Health Research Board Interdisciplinary Capacity Enhancement Award [grant number: ICE/2012/7]. TILDA is funded by the Irish Government (Department of Health), Atlantic Philanthropies and Irish Life. The funders had no involvement in the analysis or preparation of this paper. Competing interests: None declared. Ethics approval: Trinity College Research Ethics Committee. Provenance and peer review: Not commissioned; externally peer reviewed. Data sharing statement: Researchers interested in using TILDA data may access the data for free from the following sites: Irish Social Science Data Archive (ISSDA) at University College Dublin http://www.ucd.ie/issda/data/tilda/ ; Interuniversity Consortium for Political and Social Research (ICPSR) at the University of Michigan http://www.icpsr.umich.edu/icpsrweb/ICPSR/studies/34315.""Bronchiectasis is a chronic disorder characterised by permanent and irreversible abnormal dilation of the bronchi and bronchioles, primarily caused by repeated cycles of pulmonary infections and inflammation, which lead to reduced mucociliary clearance and to the excessive production of sputum.1�C3 This condition is more frequent in females and generally occurs in the sixth decade of life. The most common clinical manifestations are chronic cough, fever, excessive purulent expectoration, sinusitis and muscle fatigue. Crackles are often present on auscultation and spirometry findings show airflow obstruction.