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2, only a few regions survived FDR correction at 5%, although sub-threshold effects were observed in similar regions and in the same direction. Fig. 4 shows p-values surviving FDR-thresholding in yellow superimposed onto the uncorrected p-values indicated in red (lower panel) and corresponding beta-values encoded in color in the top panel. For descriptive purposes, Jacobians averaged in brain areas showing significant effects have been plotted by diagnosis on the right of Fig. 4 (p?selleck and beta-maps, as well as slice views showing beta-values across the entire brain, are shown in Supplementary Figs. 4 and 5, respectively. Jacobians averaged within regions showing significant effects are plotted by diagnosis on the right in Supplementary Fig. 4 (p?Metformin purchase to alcohol and/or diagnostic group membership, the log transformed Jacobian maps obtained from each child were subjected to ICA. Thymidine kinase Since the regional deformations did not relate significantly to FASD after normalization for total brain volume, ICA were performed only on the TBM analyses incorporating both linear and non-linear deformations (i.e., the unscaled data). The dimensionality of the data was reduced using principal components analysis, retaining the 10 dimensions explaining the greatest variance. These sources were examined to determine which most strongly related to AA/day or diagnostic group. A subgaussian source explaining 11.7% of the variance significantly predicted the degree of alcohol exposure, r?=??0.366, p?