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With a follow-up of 10?��?2?years, 98 total events that required hospitalization, including 13 deaths and 48 unscheduled cardiac events (UCEs), occurred. In all the CHD patients, all the CANA indices predicted the total events and UCEs. Of those, the NE level (p?=?0.0004) and BRS (p?=?0.0373) predicted the mortality. In a multivariate analysis, the BRS was an independent CANA-predictor for the total events (p?=?0.007). In the biventricular patients, the plasma NE level, heart rate variability, and BRS predicted the total events and UCEs and the BRS was the only independent CANA-predictor for the total events (p?=?0.0329). In the Fontan patients, the plasma NE level was the only Rapamycin cost predictor for the UCEs (p?=?0.0242) and no other CANA variables were independent Flavoprotein predictors of the total events or UCEs. All CANA variables, especially the BRS, were useful predictors for future clinical events in biventricular CHD patients, whereas no CANA variables, except for the plasma NE level, predicted future clinical events in the Fontan patients [23]. The aim was to investigate the effects of volume and pressure overload and increased coronary perfusion pressure on coronary flow (CF) in congenital heart disease (CHD) patients. The effects of CHD on CF are poorly mapped. A total of 65 patients with acyanotic CHD and 49 age-matched healthy controls were examined by transthoracic Doppler echocardiography. Posterior descending artery flow was measured in patients with pulmonary valve stenosis (PS) and atrial septal defects (ASDs) i.e. in lesions with right ventricular pressure or volume overload, and left anterior descending artery flow in patients with Coarctation of the Aorta (CoA) and ventricular septal defect (VSD), in lesions with left ventricular pressure or ABT-263 mw volume overload. The CF data in each patient group were expressed as the percent of the median for healthy controls from the same age group. The CF values were in VSD 172%, ASD 185%, PS 233%, and CoA 773% patients. In CoA patients body surface area (r?=?0.90, p?