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Thus, a total of 26 case�Ccontrol studies[10-16, 29, 31-48] met inclusion criteria and were included in the current meta-analysis (Fig.?1). Characteristics and genotype distribution of each case�Ccontrol study are shown in Table?1. Figures?2-5 show the summary of meta-analysis for GSTM1and GSTT1 polymorphisms with asthma risk. When all groups were pooled, the random-effects model was conducted if the heterogeneity was significant; otherwise Afatinib supplier the fixed-effects model was conducted. Twenty-six studies with a total of 3680 cases and 4350 controls were included in the GSTM1 polymorphism meta-analysis. For the GSTT1 polymorphism, 22 studies with a total of 3167 cases and 3209 controls were included. The pooled results showed a significant association for both the GSTM1 polymorphism (null vs present, OR?=?1.452; 95% CI: 1.192�C1.770; P?click here vs present, OR?=?1.792; 95% CI: 1.293�C2.483; P?Sitaxentan 95% CI: 1.018�C1.667; P?=?0.036; I2?=?36.1%), Africa (OR?=?2.175; 95% CI: 1.560�C3.031; P?