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A priori sample analysis for the study was calculated based on the assumption that the probability of a valgus patient having different (less or more) meniscus extrusion than a varus patient was 70%. Thus, a sample size of 24 valgus and 48 varus selleckchem evaluable patients was estimated to have 80% statistical power to detect a difference using the Mann�CWhitney U test with a 2-sided significance level of 0.05 (calculated using StudySize 2.0, CreoStat HB). The relationship between varus alignment and medial meniscal extrusion as well as valgus alignment and lateral meniscal extrusion was analysed with the Kruskal�CWallis test. When any statistically significant difference was observed, the Mann�CWhitney U test with Bonferroni correction was used. Meniscal extrusion was also MAO dichotomised into minor (��3 mm) and major (>3 mm) and correlated with the kind of alignment (normal, varus or valgus) using the Fisher exact test. For the variables gender and knee-side involved, the presence of any association with meniscal extrusion was calculated with the Mann�CWhitney U test. The relationships between the three groups of clinical diagnosis under study and meniscal extrusion was analysed with the Kruskal�CWallis test. Categorical variables are presented as percentages and frequencies. Continuous variables are presented as mean �� standard deviation. Statistical analysis was performed with SPSS version 15.0 for Windows (SPSS Inc., Chicago, IL, USA). The level of statistical significance Wnt inhibitor was set at p �� 0.05. According to the aforementioned measurements alignment was considered varus in 61 knees (58.7%), with an average of ?2.63��0.6��. In 27 knees (26%), a valgus alignment with an average of 2.22��0.7�� was observed. In the remaining 16 knees (15.4%), alignment was considered normal. With regard to the medial meniscus, all cases had some degree of meniscal subluxation and 18 cases (17.3%) showed major extrusion (>3 mm). In the cases with major extrusion, extrusion averaged 4.27��0.75 mm, which corresponds to 44.7% of meniscus size (range 27�C62%). The remaining 86 knees with minor extrusion (