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Thirteen patients were randomised to either the test group (N?=?6) where a PCL scaffold was inserted in the tooth socket after extraction or the control group (N?=?7) where no space filler was used. Alveolar ridge height and width measurements were made at baseline and 6?months post-extraction, for the evaluation Resminostat of bone resorption. At 6?months, a core of bone was trephined out from the healed ridge for microcomputed tomographic (micro CT) and histological analyses, immediately before Stage I dental implant surgery. Stage II dental implant surgery was performed 4�C6?months later. There was less vertical ridge resorption in the test group compared to the control group, and the difference was statistically significant in the mesio-buccal aspect (P?=?0.008). Micro CT and histological observations showed mainly mineralised bone formation in both groups, except for one specimen in the test group. The insertion of a 3D bioresorbable selleck PCL scaffold in fresh extraction sockets allowed for normal bone healing, and there was better maintenance of ridge height after 6?months as compared to extraction sockets without the scaffold. ""The aim of this study was to compare the clinical outcomes after 2?years with bone level implants placed to restore a single missing teeth that needed simultaneous augmentation and were treated with a transmucosal or submerged approach. This study analyzed a subset of patients included in an ongoing prospective multicenter randomized clinical trial (RCT) involving12 centers where patients were to be followed-up to 5?years after loading. Of the 120 implants that were placed in the original study, and randomly assigned to submerged or non-submerged healing, 52 needed simultaneous augmentation (28 women patients Lumacaftor supplier and 24 men patients, between 23 and 78?years of age). Twenty-seven of them received implants with submerged healing (AuS), while in 25 patients the implants were inserted with a non-submerged protocol (AuNS). At the 2-year follow-up visit, radiographic crestal bone level changes were recorded as well as soft tissue parameters included Pocket probing depth (PPD), bleeding on probing (BoP) and clinical attachment level (CAL) at teeth adjacent to the implant site. After 2 years a small amount of bone resorption was found in both groups (0.37?��?0.49?mm in the AuS group and 0.54?��?0.76 in the AuNS group; P?