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In both studies, trial benefits persisted further than expected beyond the intervention.62 63 Methods��Secondary statistical analyses: The secondary outcomes analyses will assess differences between groups in those secondary outcome measures listed in C) Objectives, above. Methods��Analysis of population who are non-adherent: We will use intention-to-treat analysis. As our primary analysis involves change from baseline to 24?months, missing values at midpoint will not need to be imputed. Participants who attended at midpoint measurement (or who have clinical HbA1c data subsequently), but not at final measurement, will be excluded from the primary analysis. Methods��Health economic statistical analysis: We will characterise healthcare resource utilisation by HRU for GMV and Individual Appointment arms. Costs will be assigned to each resource according to the 2013 BC Medical Guide for Fees (if related to physician billing or laboratory/procedure data); a fully allocated hospital cost model (if related to hospitalisation); and the BC PharmaCare formulary (for pharmaceutical costs). Since our analysis is focused on the Ministry of Health perspective, we are not interested in characterising non-covered direct medical costs and direct non-medical costs. Methods��Adverse events monitoring: We will ask participants to log all adverse events from PA or dietary changes. Participants in GMVs are encouraged to discuss adverse events with the nurse/exercise professional at the next GMV. Oxygenase Similarly, Control participants will be asked at their appointments whether they suffered any adverse events in the previous 3?months. Investigators will modify the intervention for a given trial participant, depending on the nature of the need and request. Any changes will be (1) specific to the need; (2) made by the PI in consultation with the other investigators; and (3) will be officially documented within UBC ethics through their postapproval process. A participant will be withdrawn from the study if requested by the participant or if the PI deems the participant's continued involvement as an unreasonable risk to their safety and/or well-being. Methods��Contingency plan Recruitment: As a contingency, we have access to four additional practices in Abbotsford should they be required (12?000 patients in total; approximately 20% over age 65?years). Should we fall short of our recruitment goal (deemed unlikely), we will add two additional clinics with five primary care physicians and 1300 total patients (all ages) in neighbouring Mission. There is also the potential to add a site on Vancouver Island (Sooke, BC). Clearly, additional sites have implications for consistency, and this will be taken into account in the design (stratification by site, planning meetings, training, teleconferences to support consistency) should it be needed. Contamination: GMV-care for T2DM is not available elsewhere in Abbotsford.