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Similarly, 24-hour data on albuminuria were available from 7 patients with mean albumin excretion Olaparib mw being 32.4 ��g/min (range 4.3-122.5), thus again just above the upper limit of normal ( 320 (patient 16) pmol/l; normal 128 nmol/l (mean �� check details SD: 73 �� 31; normal 25-200). Plasma magnesium levels were in the low-normal range with a mean of 0.73 mmol/l (n = 13), with 5 patients being hypomagnesemic (table ?(table11). Urine Volume Data on 24-hour urine volume were available in 8 patients and urine output varied between 1.3 and 8.3 (mean �� SD: 3.8 �� 1.8) ml/kg/h. Urine Calcium Excretion Twenty-four-hour urine calcium excretion was quantified in 10 patients and ranged from 0.12 to 0.68 (mean �� SD: 0.32 �� 0.17) mmol/kg/day, and was thus above the upper limit of normal (0.1 mmol/kg/day) in all. Nephrocalcinosis Data relevant to nephrocalcinosis were available in all patients. All had renal ultrasound imaging reported as consistent with nephrocalcinosis. This was confirmed by CT in a further 2 patients (fig. ?(fig.1,1, ?,2).2). In 1 patient (patient 12), nephrocalcinosis bepotastine was even reported on an antenatal ultrasound. Fig. 1 Representative ultrasound images detailing nephrocalcinosis. Shown are ultrasound images of kidneys from patient 1, right kidney, age 10 years (a), patient 3, age 16 years (b), patient 4, left kidney, age 24 years (c), patient 8, left kidney, age 12 years ... Fig. 2 Representative CT images detailing nephrocalcinosis. Shown are abdominal CT images from patient 4, age 24 years (a) and patient 5, age 9 months (b). Note the calcium densities in the kidneys (arrows).