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Screw-retained FPDs with gaps exhibited a wider range of stresses on the interproximal region of adjacent implants than cement-retained FPDs. However, severe misfit in the prosthesis caused the nonaxial stress transfer to the adjacent implants in the cement-retained FPDs with gaps. ""Deproteinized bovine bone mineral (DBBM) is one of the best-documented bone substitute materials for sinus floor elevation (SFE). DBBM is available in two particle Ritonavir sizes. Large particles are believed to facilitate improved neoangiogenesis compared with small ones. However, their impact on the rate of new bone formation, osteoconduction, and DBBM degradation has never been reported. In addition, the implant stability quotient (ISQ) has never been correlated to bone-to-implant contact (BIC) after SFE with simultaneous implant placement. Bilateral SFE with simultaneous implant placement was performed in 10 G�ttingen minipigs. The two sides were randomized to receive large or small particle size DBBM. Two groups of 5 minipigs healed for 6 and 12 weeks, respectively. ISQ was recorded immediately after implant placement and at sacrifice. Qualitative histological differences were described and bone formation, DBBM degradation, BIC and bone-to-DBBM contact (osteoconduction) were quantified histomorphometrically. DBBM particle size had no qualitative or quantitative impact on the amount of newly formed bone, DBBM degradation, or BIC for either of the healing periods (p?>?0.05). Dabrafenib price Small-size DBBM showed higher osteoconduction after 6 weeks than large-size DBBM (p?Selleckchem SCH772984 in the literature, when an electroeroded definitive cast-titanium fixed prosthesis is used for this treatment protocol. Purpose: The aim of this study was to evaluate the clinical effectiveness of dental implants (Astra Tech Dental, M?lndal, Sweden) in the edentulous mandible immediately loaded with an electroeroded cast-titanium screw-retained fixed prosthesis. Materials and Methods: Forty-five patients received five implants each in the interforaminal area. All the implants were inserted with torque up to 40?Ncm and the distal implants were distally tilted approximately 20 to 30 degrees to minimize the length of posterior cantilevers. Implants were loaded within 48 hours of placement with an acrylic resin-titanium screw-retained prosthesis fabricated by electroerosion.