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This view draws on evidence that contextually-rich episodic and spatial information within memory almost always activates the hippocampus. Thus consolidation of these memories differs from the cortical networks involved in the retrieval of more semantic, or non-declarative, knowledge. The multiple trace theory therefore has weight in that it addresses the differences between context or experience-based memories, and knowledge, though adds a layer of complexity to understanding the processing of most AMs, which comprise both episodic and semantic elements (Renoult et al., 2012). Whilst both accounts of systems consolidation imply that memories can be set down into relatively stable structures, it is widely acknowledged that such memories can be subject to change and refinement over time (Alberini and Taubenfeld, 2008). Indeed our comprehension of the AM system (e.g., Conway and Pleydell-Pearce, 2000) serves as a reminder that retrieved memories are rarely recalled truly episodically. Rather, fragments of information about an experience, perceptions of it and information gained since an experience will be mixed in with the original experience, leading to different kinds of memory integration and transformation, such as gist extraction and insight generation (Payne, 2010; Wamsley, 2014). In this way memories are ever-changing. This is likely true of all kinds of memories, such as procedural knowledge (learning how to drive a car for instance) in addition to autobiographical experiences, for which construction is already a well-documented feature. ��Re-consolidation�� refers to the Carboplatin processes whereby recalling a memory re-activates and slightly changes it, requiring it to be re-integrated into ever refined semantic structures (Nader, 2003). Thus the time-course of consolidation processes reflects the malleable nature of remembering. Consolidation is not instantaneous, which falls in line with this view. Rather it occurs over hours, days, weeks and perhaps even longer (see Frankland and Bontempi, 2005). Sleep is largely seen to be the state during which most memory consolidation takes place (see Payne et al., 2008a, for a thorough review). During sleep external stimuli are not perceptible, unless salient or loud enough to rouse the sleeper. Here the brain enters a reflexive state in which thoughts and experiences are internally generated (e.g., Maquet, 2000). Thus consolidation allows for previously encoded and accessible memory traces to be activated in some form without the interference of new stimuli.