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However, further investigations should be performed to assess whether antiretroviral-associated hepatotoxicity can be predicted by alterations in individual bile acid concentrations. ""Study Objective. To assess blood pressure control after discontinuation of a physician-pharmacist collaborative intervention. Design. Comparative analysis of data of the patients who received the intervention E-64 versus a control group from a prospective, cluster-randomized, 9- month efficacy trial and the same patients' data 18 and 27 months after completion of the trial, abstracted from their medical records. Setting. Five primary care medical offices operated by a university health system. Patients. One hundred four patients with hypertension; 65 were in the intervention group, and 39 were in the control group. Measurements and Main Results. In the prospective study, patients were randomized to receive a physician-pharmacist collaborative intervention to improve blood pressure control or to the control group. Systolic and diastolic blood pressures were measured by a research nurse at baseline and at the end of the study (9 mo later). In the current study, data were abstracted for blood pressure and blood pressure control at 18 and 27 months (9 and 18 mo, respectively, after discontinuation of the study). At baseline, mean �� SD systolic blood pressure was 152.5 selleck inhibitor �� 9.5 and 150.1 �� 9.6 mm Hg in the intervention R428 cell line and control groups, respectively (p=0.22). At 9 months, systolic blood pressure decreased to 124.5 �� 10.7 and 132.0 �� 15.1 mm Hg (p=0.0038 between groups), and blood pressure was controlled in 78.5% and 48.7% (p=0.0017) of patients in the intervention and control groups, respectively: By 18 months, systolic blood pressure had deteriorated to 131.0 �� 12.2 and 143.3 �� 17.5 mm Hg (p