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8.0 statistical software. 2.9. Ethics The study was approved by the Institutional Review Board of the Mexican Institute for Social Security (IMSS) of the participating hospital (approval number IMSS R-2010-1303-29), anti-PD-1 monoclonal antibody with all subjects providing written informed consent. 3. Results Figure 1 presents the study's flow chart of the patients meeting the inclusion criteria. Of 54 RA patients with a suspicion of ILD, 15 were excluded from the study because they declined to participate (n = 5) or had exclusion criteria for the study (n = 10), whereas, of 59 RA patients without ILD, 17 were excluded because they met one of the exclusion criteria (see Figure 1). Figure 1 Study flow chart. RA: rheumatoid arthritis; RA-ILD: rheumatoid arthritis with interstitial lung disease; PFT: pulmonary function tests; HRCT: high-resolution computed tomography; FVC: forced vital capacity; anti-CCP: anti-cyclic citrullinated peptide ... Table 1 compares the characteristics of patients with RA-ILD (n = 39) versus RA only (n = 42). Patients with RA-ILD had higher scores for DAS28 (3.9 versus 2.5, P Crenolanib ic50 and HAQ-Di (0.8 versus 0.4, P Selleck Lapatinib disease (RA-ILD) and patients with RA without interstitial lung disease (RA only). Figure 2 illustrates a comparison between anti-CCP2 titers in patients with RA only, compared with RA-ILD. Higher anti-CCP2 titers were observed in RA-ILD (77.9 versus 30.2, P