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Ten deaths were from cardiac causes including five sudden deaths in the community. Of the 17 non-cardiac deaths, 8 were from dialysis withdrawal, 7 from sepsis and 2 from other causes. Patients who died had higher hsT levels (median 109, IQR 60�C158) compared with those alive at 6 months (median 59.5, IQR 35�C96, P = 0.0007). hsT was higher in patients who died from CV causes (median 418, IQR 109�C776) versus alive (median 59.5, IQR 36�C96, P = 0.0027), but was modestly and not significantly increased in patients who died from non-CV causes of death (median 76, IQR 48.5�C113 versus alive 59.5, IQR 36�C96, P = 0.24). In a univariate analysis with CV death as the primary outcome, the most significant risk factor was an elevation in the baseline troponin T level (Table?3), while a low ejection Epigenetics inhibitor fraction and elevated C-reactive protein were also significant predictors of CV deaths. An increase in baseline troponin levels by 100 units increased 3-mercaptopyruvate sulfurtransferase the odds of CV deaths (OR 1.5, 95% CI 1.182�C1.918; P = 0.0009). This remained significant in multivariate analysis after adjustment for ejection fraction and C-reactive protein (OR 1.32, 95% CI 1.066�C1.657; P = 0.011). Table?3. Associations with CV death: univariate analysis Variation in troponin T levels Seventy-eight patients underwent testing of hsT prior to a routine dialysis session 1 month after the initial hsT testing. Three subjects were not included in the variation analysis because they had clinical evidence of severe unstable cardiac disease or an acute coronary syndrome. In these patients, hsT varied by >100% and >100 ng/L (Table?4). Table?4. Characteristics of patients with variation of high-sensitivity troponin of >100 ng/L For the remaining 75 subjects, the average pre-dialysis hsT did not change over the month (76.1 IQR 43�C93 versus 76.0 IQR 43�C103). In 95% of all patients (2SD), variation over 1 month was www.selleckchem.com/products/kpt-330.html Dotted and solid lines indicate median difference and 2SD (95%). (B) Percentage change in hsT T levels between the two measurements 1 month apart. Dotted and solid lines ... Decrease in troponin T over dialysis In the second month, hsT levels were evaluated at the start and end of a dialysis session in 75 subjects. The average level before dialysis was 76 (IQR 43�C103) ng/L and at the end of the dialysis session, 66 (39�C86) ng/L (P