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5 year follow up. 38 of 43 (88%) athletes achieved limited return to sport, with full return to pre-injury level possible in 34 of 43 (79%) athletes at 9.6 �� 3.0 mo after the procedure. Statistically significant increases from baseline to the most recent follow up was reported in Activities of Daily Living Score from 62.0 to 82.8 (P LY294002 chemical structure Raz et al[29] reviewed 58 cases of osteochondral allograft transplantation to the distal femur with an average follow up of 21.8 years. 13 of 58 cases required further surgery of graft removal or TKA, and 1 case underwent multiple debridements before above-the-knee amputation. Kaplan-Meier analysis revealed graft survivorship of 91%, 84%, 69% and 59% at 10, 15, 20 and 25 years, respectively. A mean modified HSS score of 86 was reported for patients with a surviving allograft at 15 years or more post-operatively. Radiographic evidence was available for 55 of 58 patients at 10 or more years following surgery. Graft sclerosis and fragmentation was seen in 10 patients, non-union was seen in 5 patients and successful graft incorporation buy Lapatinib to host was observed in 40 patients. Tibia Sixty-five patients, all with post-traumatic tibial plateau fractures, received fresh osteochondral allografts for reconstruction of the tibial plateau with an average follow up of 11.8 years in a prospective non-randomized study by Gross et al[23]. Survivorship analysis revealed 95% survival at 5 years and 80% survival at 10 years and 65% at 15 years. Twenty-one patients required knee arthroplasty after graft failure. At the end of the study period, the mean modified HSS score was 85.3 for the intact grafts. In a study by Bakay et al[6] post-traumatic defects of the tibial condyle were treated with cryopreserved allografts with additional metal fixation screws in 5 patients with an average 2 years S6 Kinase follow up. Three cases were successful and reported excellent or good clinical results. Two cases of failures were reported in patients both aged over 40 years; 1 graft disintegrated and 1 graft was implanted technically incorrectly, producing a poor clinical result. Ghazavi et al[30] reported on the use of fresh osteochondral allografts to reconstruct post-traumatic defects in 126 knees of 123 patients with a mean follow up of 7.5 years. The locations of the lesions were: tibial plateau (63), femoral condyles (50), bipolar tibial and femoral (8) and patellofemoral (2).