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One patient had an ALT/AST elevation ��3x ULN at week 4, with levels returning to Selleck S3I 201 was reported, and ALT levels returned to selleck ��1.2 units from baseline) was achieved in 92% of patients at week 24, with a mean time to response of 36.4 �� 2.4 days (Figure 2(b)). High disease activity observed in 63 (66.3%) patients at baseline decreased over time, and no patients demonstrated high disease activity at the end of the study. In total, 22 (23.2%) patients had low disease activity (DAS28 ��2.6 to ��3.2) at week 24. The highest proportion of patients reporting low disease activity occurred at week 12 (36%). The proportion of patients with disease remission (DAS28 Quinapyramine these were sustained through week 24 (12% and 11% of patients had abnormal ESR and CRP values, resp., at study end). Mean ESR and CRP levels decreased significantly after the baseline visit, with the lowest levels observed at week 16 for both (P