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Notes Financial or Other Competing Interests None.""Cysticercosis of the central nervous system (CNS) called as neurocysticercosis (NCC) is known to be a debilitating infectious cause of neurological disorders in human since many decades in the past particularly in the tropical developing countries [1]. However, only recently its importance is being recognized as a potential human to human transmitted parasitic disease, and the major cause of epilepsy; thus causing a significant neurological health problem and disability particularly in the tropics [2�C6]. Acute epileptic seizure with altered sensorium and raised intracranial pressure may require ventilatory support in an p38 MAP Kinase pathway intensive care unit that remains as the mainstay of management of NCC during acute presentations [7]. Human gets infected either by accidental ingestion of Taenia solium eggs through contaminated food or vegetables or due to endogenous autoinfection because of the carriers of the adult worm in their intestine; by either means eggs containing the hexacanth larvae disseminate hematogenously to the brain developing into metacestode larvae or cysts. A recent meta-analysis summarizes the proportion of NCC among patients with epilepsy (PWE), and suggests that in endemic communities nearly one-third of PWE are living with T. solium cystic lesions in their brain [8]. This disease is known to be highly endemic in Indian subcontinent and the whole of South East Asia [9]. In a recent Indian study, 89.66% cases having neurological manifestations with inflammatory granulomas were found consistent with diagnosis of NCC [10]. However, the serodiagnostic confirmation was not performed in those cases. NCC was found to be associated with approximately one-third of all cases presenting with active epilepsy in either urban or rural regions as per a study reported from Vellore district of Tamil Nadu (India) [11]. The pleomorphic and unpredictable course of NCC can be related to the biological stage of the parasites, their numbers as well as the immunegenetic factors in man [12]. Though India is known to be highly endemic, there are many provinces where reports are still unavailable or scanty thereby underestimating its actual burden in this country [13]. The present study is done in Odisha that is considered to be a Gate way to the eastern India, located on the Bay of Bengal coast. With the rapidly changing economy as well demography, the underlying prevalence of T. solium cysticercosis was never explored in this area. From this region, the first published case of NCC (as per MEDLINE database) was identified in a psychiatric patient with a manic episode of seizure which was confirmed by CT scan of brain in one of the major medical center in Cuttack. In that case, psychiatric manifestation showed a gradual decline following treatment with medication [14].