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603, PCeftiofur some combinations of attribute levels. While we decided to not extrapolate beyond the US $70 maximum cost level that was included in this survey, we would consider increasing slightly the highest monthly cost levels if we were to repeat this study. Nonetheless, US $70 is higher than the cost of the treatments that were on the market at the time of the research and increasing the pricing much beyond the relevant range may decrease respondent attention to the price attribute [51]. Utility balance was not imposed on the experimental design. While utility balance has been included as an important criterion for DCE design, in addition to orthogonality, D-efficiency, and level balance, it has come under substantial criticism lately [52]?and?[53], with Huber stating [52], ��Utility balance has failed as a design criterion. Primary design concerns are that respondents understand the task involved in the DCE questions, can Selleck Sunitinib adequately answer the questions, consider the attributes and levels presented in each choice task, do not lose focus through boredom, and complete all the tasks. Evolving general guidelines, rather than rules, tend to influence the development of DCE��and those evolve. Many DCEs have between three to five alternatives per choice task and some have upwards of 20��we chose three as a design that would provide a reasonable quantity of data while not overburdening the cognitive abilities of respondents when considering each choice task. The effects, if any, of respondent fatigue have become an increasingly important and evolving topic for DCE researchers. Rolfe and Bennett [54] www.selleckchem.com/products/3-methyladenine.html found that respondents were able to more easily analyze the choice sets and to make decisions when presented with three alternatives per choice set, rather than two, and that there was greater serial nonparticipation and higher rate of ��not sure�� responses in the two alternative formats. The DCE design included 14 choice tasks, with the common range being 12 to 16 tasks. Overall, the design characteristics of this study fall within the general range of suggested parameters for DCE designs. As is the case with all surveys, our results and conclusions are based on the attributes and levels included in this DCE.