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""Purpose: Symptomatic venous thromboembolism (SVTE) is a potentially significant complication which may occur following injury or surgery. The NICE framework was established despite a complete lack of evidence with no studies investigating the risk factors for or incidence of SVTE in NOF. We aim to produce a validated risk score to inform clinical practice. Data from a prospective series of 9167 consecutive patients with a diagnosis of fractured neck of femur (NOF) at a single institution were used to construct a risk score for SVTE. All patients were treated with in-patient anticoagulation. Twenty three factors were screened Selisistat in vivo with pairwise analysis for potential association with SVTE. The cohort had an event rate of 1.4%. A multiple logistic regression model was used to construct a score and correct for confounding variables from nine significant factors in the pairwise analysis. Four factors; length of stay; chest infection; cardiac failure and transfusion were used to produce the final risk score. The score was statistically significant (p?PDE4B NotSVTE score were found to be individually statistically significant (p?see more the best results. Methods: A systematic review of the published literature was performed, searching Medline for English language studies that reported functional or radiographic outcome following single-bone fixation of either bone by any method in patients less than 18 years old with both-bone diaphyseal forearm fractures. Results: 11 studies met the inclusion criteria. They were all retrospective studies (Level of Evidence III or IV). Five studies compared single- with both-bone fixation and reported similar outcomes in general.