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It was found that both RVEF (hazard ratio [HR]: 0.938; 95% confidence interval [CI]: 0.902 to 0.975; p = 0.001) and PVR (HR: 1.001; 95% CI: 1.001 to 1.002; p = 0.031) were associated with survival. In addition, age and connective-tissue�Cdisease PAH were associated with outcome. Multivariable analyses showed that RVEF and PVR remained significantly associated with survival after correction for age and type of underlying diagnosis (RVEF: HR: 0.921, 95% CI: 0.884 to 0.959, p find more high PVR (HR: 2.296; 95% CI: 1.016 to 5.184; p = 0.046) were associated with mortality. Bivariate analysis showed that a low RVEF was independently associated with poor survival (HR: 0.260; 95% CI: 0.101 to 0.670; p = 0.005). Figure 2 shows Kaplan-Meier survival analyses based on the cut-off values of PVR and RVEF. Patients with low RVEF (groups 3 and 4) had significantly poorer prognosis compared with patients with high RVEF (groups 1 and 2), regardless of their PVR (Fig. 2C). Bivariate Cox PD0332991 datasheet regression analysis applied to the combination of the binary values of RVEF and PVR showed that the patients with high RVEF/high PVR (group 2) did not have a different prognosis compared with the patients with high RVEF/low PVR (group 1) (p = 0.579). Patients with low RVEF/low PVR (group 3) had similar prognosis compared with patients with low RVEF/high PVR (group 4) (p = 0.830). In addition, patients of group 3 and patients of group 4 had 5.2 times greater HRs compared with high RVEF/low PVR patients (group 1) (p PTEN After a median period of 12 months (IQR: 10 to 16 months) of PAH-specific medical treatment, pulmonary pressures remained almost unaltered, whereas PVR was significantly decreased. In addition, cardiac index was improved and the 6MWT was stable. No other changes in cardiac functional parameters were observed (Table 4). Furthermore, with respect to the effects of the different classes of drugs, we found no significant differences between groups (Table 5). Changes in PVR correlated moderately with changes in RVEF (R = 0.330; p = 0.005) (Fig. 3). PVR decreased in both survivors (?121 �� 297 dyne��s��cm?5) and nonsurvivors (?132 �� 432 dyne��s��cm?5) (p = 0.927). Changes in RVEF differed significantly between survivors (+3% �� 9%) and nonsurvivors (?5% �� 6%) (p