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9 vs. 62.3, p?learn more amputees (83% vs. 74%, p?=?0.026). No upper extremity amputees were found FIT and only 12 (8.3%) were allowed COAD ( Table 3). The most impactful non-upper extremity amputation-related disabling conditions for the upper extremity amputees were post-traumatic stress disorder (PTSD) (17%, impact?=?1260), loss of nerve function (12%, impact?=?630), and facial injuries (7%, impact?=?480) ( Table 4). The upper extremity amputees were also significantly more likely to have disability from PTSD (p?=?0.02) and loss of nerve function (p?=?0.03) than the general amputee population. Several studies have characterised injury trends, amputation characteristics, and overall disability in the military population since buy ABT-888 the beginning of OIF/OEF [1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11]?and?[12]. The majority of literature has focused primarily on the characteristics, treatment, and disability associated with severe lower extremity trauma and amputations. However, upper extremity amputations account for nearly one-fifth of all amputations in the amputation cohort studied and have not been well characterised. The purpose of this study is to better characterise these upper extremity amputees and their disabling characteristics in comparison to the isolated lower extremity amputees and the general amputee population. This study provides the largest analysis of upper extremity amputees, to date. The overall upper extremity amputation rate in this cohort was 14%. This rate is lower than the previous reports regarding wartime injury patterns. Dougherty et al. [10] found the rate of upper extremity amputations to be 50% among all extremity amputations PDE4B seen at Naval and Marine treatment facilities during a 1-year period. In more inclusive studies regarding military amputations, Stansbury et al. [5] and Stinner et al. [7] found the rate of upper extremity amputations to account for approximately 25% and 22%, respectively. Furthermore, this study showed similar rates of trans-radial amputations as previously reported by Stansbury et al. [5]. This study incorporated data from multiple databases designed to track injury characteristics at multiples echelons of care and treatment facilities. Consequently, we were able to capture a greater number of total amputees than previously reported. The more inclusive nature of this report may account for the lower rate of upper extremity amputations. Furthermore, this lower rate may represent changes in injury patterns over time or improvements with the protective gear donned by service members.