Most Disregarded Formula For The MDV3100

10)19 and Brandsson's study (I2=41%; p=0.09).17 In order to facilitate and standardise data pooling, the results (mean VAS scores: WMD ?1.75; 95% CI ?2.16 to ?1.33; p results. A Begg's funnel plot did not show any substantial asymmetry (figure 3), and Begg's rank correlation test did not indicate publication bias among the included studies (mean VAS scores: p=0.755; last VAS scores: p=1.000). Table?3 Results of sensitivity analyses Figure?3 Funnel plots with relative ratios or WMDs of all studies comparing single-dose Telomerase intra-articular bupivacaine-morphine with placebo. The vertical axis represents effect value, and the abscissa represents the SE of the effect value. The horizontal line in ... Number of patients requiring supplementary analgesia Eight articles11 12 15 16 19�C22 reported the number of patients who required supplementary analgesia. This number was significantly lower in the bupivacaine plus morphine group than in the placebo group (RR 0.60; 95% CI 0.39 to 0.93; p=0.02). Substantial heterogeneity was observed (I2=65%; p=0.02). The results are shown in figure 4. Figure?4 Forest plot of number of patients requiring supplementary analgesia. Sensitivity analysis showed inconsistency in the results (table 3). There was no significant difference in the results (RR 0.66; 95% CI 0.43 to 1.02; p=0.06) after excluding one study15 where treatment also included epinephrine. Further exclusion of single studies indicated that the overall RR only changed substantially when the study by Hosseini et al11 was excluded (RR 0.64; 95% CI 0.39 to 1.05; p=0.08). Begg's funnel plot did not show any substantial asymmetry, and Begg's rank correlation test did not indicate publication bias among the included studies (p=0.902). Time to first analgesic request Three articles11 16 21 reported the time interval until the first request for additional analgesia. The combined data suggested no significant difference (WMD 3.46; 95% CI ?1.81 to 8.72; p=0.20) between the bupivacaine plus morphine group and the placebo group. Great heterogeneity (I2=100%; p