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73?m2 measured at least 90?days apart. Lists of nephrotoxic agents (including IV BP, chemotherapy, biologic therapy, and targeted therapy) and anticancer agents were predefined based on literature review and expert clinical consultation. Results are reported overall, and in some cases by tumor type: breast, prostate, lung, renal or other. The demographic and clinical characteristics of the study population, including mean eGFR and renal status based on assessments in the 3?months prior to and 1?month after bone metastasis diagnosis, were summarized. We estimated the prevalence of RI and of CKD in 2009�C2013 for the study population overall and stratified by tumor type. We also examined distribution of these patients across eGFR categories: selleck products agent in the 12?months prior to and Pifithrin�� 12?months after the lowest recorded eGFR. Among CKD patients, use of these agents was assessed in the 12?months prior to and 12?months after the date of the confirming (second) eGFR value. Results A total of 24,512 patients with diagnoses of solid tumors and bone metastasis were identified. Among these patients, 11,809 (48%) met the inclusion criteria. The criterion for patients to have at least one serum creatinine value recorded during the study period eliminated ?36% of the patients who met the criteria applied earlier in the selection process (Fig.?(Fig.11). Figure 1 Patient selection. Demographic and clinical characteristics of the study population are presented in Table?Table1.1. Females comprised just over half of the study population (51%), and the majority (66%) of the patients were Caucasian. On average, patients were 67?years old at the time of their bone metastasis diagnosis. PDK4 Table 1 Characteristics of study patients (N?=?11,809) Breast and lung cancer were the most common tumors, accounting for 34% and 28% of the study population, respectively. Of the 11,189 (95%) patients with a serum creatinine assessment around the time of bone metastasis diagnosis, the mean eGFR was 77.3?mL/min per 1.73?m2 and 24% exhibited RI (eGFRs