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As described elsewhere,[28] separate simple linear regression functions have been fitted to obtain the equations for normal lung function values INCB024360 (FEV1 and FVC, respectively). The regression coefficients for each lung function parameter were estimated in separate simple linear regression models, for each sex, after log-transformation (natural logarithm) of the body height and the respective lung function parameter. These coefficients were subsequently transformed back to the original scale for a more straightforward interpretation and use of the resulting normal equations. The simple linear log-transformed regression functions were chosen based on published models in order to allow for a straightforward comparison with those models and the concerned populations. Statistical calculations were performed using SAS?, version 9.1 (SAS Institute, Inc., Cary, NC), figures were created using Microsoft Office Excel? 2007. From the total of 1,236 children, 1,093 were healthy, able to perform a suitable spirometry, and thus eligible for the study. The children in this group, of which 51% were female, were on average 10.31 years old (SD 1.55), 134.9?cm high (SD 11.9), and weighed 29.4?kg (SD 9.7; Table 1). None of the children ever had done a lung function. Of all 1,236 RhoC children tested, 143 had to be excluded for varying reasons, most of them (n?=?128) because they were unable to perform a viable and reproducible spirometry. Body Mass Indices (BMI) tended to be generally low with a mean value of 15.8?kg/m2 (SD 3.0). The age adjusted centiles for the BMI compared to American children were 29.9 on average.[32] The values obtained from private and public students differed from one another with the latter having significantly lower BMIs (mean centile: 20.7 vs. 42.7, P?GSK1210151A manufacturer volumes from Malagasy children were compared to Caucasian children through Z-scores. Lower Z-scores for FVC (?1.45, SD 1.03) and FEV1 (?0.93, SD 1.06) were observed using reference data for Caucasian children provided by Stanojevic.[33] Significant differences were found between male and female students regarding FEV1 (males: ?0.85, females: ?1.00; P?=?0.0147) but not FVC measures. Values for students of private and public schools showed a pronounced difference for FVC (private schools: ?1.32, public schools: ?1.54; P?=?0.0004) and FEV1 (private schools: ?0.82, public schools ?1.01; P?=?0.0023; Table 3).