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The results of multivariate logistic models were approximated by odds ratio with its 95% confidence interval (OR [95%]). A 2-sided P value INCB018424 result. Prevalence of all aPL tested is shown in Table 3. Overall, 169 patients experienced pregnancy morbidity defined by APS criteria and 41 (24%) of them showed permanent positivity for at least one of the measured aPL. The highest prevalence was found for aCL and aPS/PT (13%) while the prevalence for LA and anti-��2GPI was lower (7%) (Table 3). Eleven patients (6.5%) were aPS/PT positive while being negative for all other tested aPL. Six of them had recurrent abortions before 10th WG, two experienced an unexplained death of a morphologically normal fetus past 10th WG, one delivered prematurely, and two experienced both recurrent abortions and premature birth. Considering Sydney revised laboratory criteria of APS, 17.8% (30/169) of patients were positive for LA or aCL and/or anti-��2GPI. Among them, 22 were treated with low-molecular-weight heparin (LMWH) and low dose aspirin (LDA) which resulted in a successful pregnancy. find more Six women had no subsequent pregnancies; three of them experienced successful pregnancy prior to APS pregnancy complications. Two women had unsuccessful subsequent single pregnancies despite the anticoagulant treatment. When adjoined, the aPS/PT results revealed an additional 6.5% (11/169) of patients with adverse pregnancy outcome that was positive for aPL. Table 3 Prevalence of aPL in patients with obstetric complications and healthy AZ191 controls. The frequency of aPL among 42 patients who experienced less than three miscarriages before 10th WG (and did not meet APS classification criteria) was very low and did not show differences from healthy women. Statistical analyses could not find any association of higher levels of aPL being more strongly associated to adverse pregnancy outcome. When analyzing each of the three categories of pregnancy morbidity included in the APS classification criteria only aPS/PT antibodies were statistically significantly associated with either of three types of adverse pregnancy outcome (P