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All questions from the original mailed questionnaire were repeated and completed. AZD3759 solubility dmso Statistical analyses were performed in SAS software, version 9.2 (SAS Institute, Cary, NC, USA), and SPSS, version 17.0 (SPSS Inc., Chicago, IL, USA). Logistic regression analysis was used to calculate the odds of having a relevant exposure in subjects having undergone one or more FESS, compared to control subjects. A proportional odds model (POM), which allows more than two ordered response categories, and a Poisson regression model with log link, handling the number of FESS as count data, were used to analyze the relationship between an increasing number of FESS and exposure state. Possible confounding by asthma, current smoking state, presence of nasal polyps, and atopy was investigated by three-way analysis of contingency tables and by examining their relationship with both predictor and response variables in the POM and Poisson regression model. All tests were two-sided with ��?=?0.05, and results are presented as odds ratios (OR) with 95% confidence intervals (95% CI). Of the 890 patients undergoing FESS, 467 returned a filled questionnaire check details (52.5% response rate), compared with 69 of 182 control subjects (37.9% response rate). Of the patients undergoing FESS that responded, 59.5% had undergone one surgery (n?=?278), 25.7% two surgeries (n?=?120), 9.0% three surgeries (n?=?42), and 5.8% (n?=?27) had undergone four or more surgeries. About 27% of the patients undergoing FESS were diagnosed with nasal polyps (n?=?126). General patient characteristics are listed in Table?1. Active smoking, atopy, and self-reported asthma were more prevalent among cases than among controls; the prevalence of atopy and ATP12A asthma increased significantly with increasing number of FESS (Table?1). Among all patients undergoing FESS, 25% reported a ��relevant�� occupational exposure, which is significantly higher than the 12% found among controls (Fig.?1). The OR for reporting a relevant occupational exposure was 2.45 [95% CI 1.14�C5.29] among patients having had at least one FESS when compared to those who had no FESS. Moreover, the proportion of patients with a relevant occupational exposure increased with the number of FESS procedures: from 21% in those operated once to 26%, 31%, and 44% in those operated two times, three times, and more than three times, respectively (��2?=?12.74; P?