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Olcegepant site Implementation Science (2016) 11:86 DOI 10.1186/s13012-016-0449-STUDY PROTOCOLOpen AccessA national evaluation of a dissemination and implementation initiative to improve principal care practice capacity and strengthen cardiovascular disease care: the ESCALATES study protocolDeborah J. Balasubramanian3, Leah Gordon1, Miguel Marino1, Sarah Ono1,four, Leif I. Solberg5, Benjamin F. Crabtree6, Kurt title= j.1467-9507.2007.00408.x C. Stange7, Melinda Davis1,8, title= peds.2015-0966 William L. Miller9, Laura J. Damschroder10, K. John McConnell11 and John CreswellAbstractBackground: The Agency for Healthcare Investigation and High quality (AHRQ) launched the EvidenceNOW Initiative to swiftly disseminate and implement evidence-based cardiovascular disease (CVD) preventive care in smaller sized main care practices. AHRQ funded eight grantees (seven regional Cooperatives and a single independent national evaluation) to participate in EvidenceNOW. The national evaluation examines high-quality improvement efforts and outcomes for greater than 1500 smaller key care practices (restricted to these with fewer than ten physicians per clinic). Examples of external support contain practice title= pnas.1222674110 facilitation, professional consultation, functionality feedback, and educational MedChemExpress MK-3102 components and activities. This paper describes the study protocol for the EvidenceNOW national evaluation, which can be known as Evaluating Method Transform to Advance Mastering and Take Proof to Scale (ESCALATES). Procedures: This prospective observational study will examine the portfolio of EvidenceNOW Cooperatives utilizing both qualitative and quantitative information. Qualitative information incorporate: on the internet implementation diaries, observation and interviews at Cooperatives and practices, and systematic assessment of context in the perspective of Cooperative team members. Quantitative information involve: practice-level overall performance on clinical top quality measures (aspirin prescribing, blood stress and cholesterol manage, and smoking cessation; ABCS) collected by Cooperatives from electronic wellness records (EHRs); practice and practice member surveys to assess practice capacity as well as other organizational and structural qualities; and systematic tracking of intervention delivery. Quantitative, qualitative, and mixed strategies analyses will be carried out to examine how Cooperatives organize to supply external assistance to practices, to examine effectiveness on the dissemination and implementation approaches they implement, and to examine how regional variations as well as other organization and contextual components influence implementation and effectiveness. Discussion: ESCALATES is usually a national evaluation of an ambitious large-scale dissemination and implementation work focused on transforming smaller sized main care practices. Insights will aid to inform the design and style of national health care practice extension systems aimed at supporting practice transformation efforts in the USA.(Continued on subsequent page)* Correspondence: cohendj@ohsu.edu 1 Division of Family members Medicine, Oregon Wellness Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USA two Division of Healthcare Informatics and Clini.Pt to BioMed Central and we are going to help you at every step:?We accept pre-submission inquiries ?Our selector tool helps you to find essentially the most relevant journal ?We provide round the clock client assistance ?Handy online submission ?Thorough peer assessment ?Inclusion in PubMed and all significant indexing services ?Maximum visibility for your analysis Submit your manuscript at www.biomedcentral.com/submit Cohen et al. Implementation Science (2016) 11:86 DOI 10.1186/s13012-016-0449-STUDY PROTOCOLOpen AccessA national evaluation of a dissemination and implementation initiative to enhance key care practice capacity and increase cardiovascular disease care: the ESCALATES study protocolDeborah J.