Rapamycin Finally Got You Straight Down? Now We Have The Solution

The transplant databases at three institutions were queried from January 1, 1999, to December 31, 2008, at IRS1 the following institutions: Arkansas Children's Hospital, Little Rock, Arkansas, Children's Memorial Hospital, Chicago, Illinois, and St. Louis Children's Hospital, St. Louis, Missouri. Institutional review board approval was obtained at all three institutions prior to data collection. All patients who underwent HTx as infants at these three institutions ( did not change during the study period. During the immediate post-operative period, standard inotropic support was initiated, including milrinone, dopamine, and epinephrine. In addition, inhaled nitric oxide was used in situations with elevated pulmonary vascular resistance. Immunosuppression therapy comprised of induction therapy with high dose methylprednisolone and antithymocyte globulin as per institutional protocol. Typically, tacrolimus was started on post-operative Rapamycin order day 4 and mycophenolate mofetil on post-operative day 3. If the patient was on ECMO, induction therapy was started after decannulation and when the chest was closed to prevent the risk of infection. All patients were cannulated in the operating room or in the intensive care unit. In the Selleck JQ1 majority of cases, patients were cannulated centrally via the aorta and right atrium. Additionally, the left ventricle was decompressed with a left ventricular vent via the left atrial appendage. No other mechanical support was used in these patients. At time near ECMO decannulation, inotropic support was initiated, ventilator support was increased, and ECHO was used to assess cardiac function. Chest closure was usually delayed by another 48?h after decannulation. Data are presented as mean?��?s.d. Group comparison was performed using an unpaired Student's t-test with significance p Value