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Although fasting blood sugar, 2-hour postprandial glucose, and glycosylated hemoglobin showed a significant increase in the IGT and type 2 DM groups compared with controls, there was no significant difference in these parameters between the obese and nonobese subgroups (Table 1). Table 1 Results for PS-341 concentration age, BMI, glucose tolerance, lipid profile, oxLDL, and oxLDL antibodies in the study groups OxLDL was found to be significantly increased in the IGT group when compared with controls (P between obese and nonobese subjects in the same group, there was no significant difference between the means of each subgroup. Mean anti-oxLDL antibody levels were increased significantly lazabemide in the IGT group (40.4��17.6 U/L, P 1). Figure 1 Anti-oxidized LDL antibodies in the study groups. Figure 2 shows a positive correlation between oxLDL levels and oxLDL antibody levels in the study population (r=0.59, P LDL antibodies. Figure 3 Correlation between anti-oxidized LDL antibodies and body mass index. Discussion Modified lipoproteins are immunogenic in humans and in animal models.12 Of all the modified forms of LDL, oxLDL and MDA-LDL are the most extensively investigated in biomedical research. OxLDL, because they are no longer recognized by LDL receptors, form immunogenic epitopes leading to formation of antibodies; the predominant isotype GSK1120212 of oxLDL antibodies is IgG, of subclasses 1 and 3.13 These antibodies are attracting considerable attention in biomedical research in terms of their pathogenic or protective clinical role and the biochemical and anthropometric measures associated with elevated levels of these antibodies. The present study investigated the association between increased levels of anti-oxLDL antibodies and obesity in different glycemic situations. Our data indicated higher levels of anti-oxLDL antibodies in the type 2 DM group (P