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Only significant (p �� 0.05), or marginally significant (p �� 0.10), associations are described. Specific to the control variables, participant age was positively correlated with RD (r = 0.15, p = 0.01). Also, participants recruited from the health department STD clinic were more Saracatinib clinical trial likely to report high depressive symptoms (40.9%) than those recruited from the adolescent clinic (32.3%), and the reproductive health clinic (27.7%); ��2 = 5.24, p = 0.07. Among the psychosocial factors, interpersonal stress (r = 0.40, p status was not significantly related to depressive symptoms (r = 0.03, p = 0.67), nor were participants with an s allele more likely to report higher RD (43.2%) than those in the ll allele group (40.7%); ��2 = 0.19, p = 0.66. Multivariable Hierarchical Logistic Regression Predicting Level of Depression Symptoms Overall, we found that the three step model including the interaction term was significant (see Table ?Table22). The interaction between RD and 5-HTTLPR group was significantly associated with the probability of being in the high depressive symptom group above and beyond the psychosocial factors. In order to interpret the interaction effect, separate multivariable logistic regression models for level of depressive symptoms were conducted for those possessing one or two copies of the s allele and those with the ll allele (see Table ?Table33). For both those with the s and the ll genotypes, having higher interpersonal stress and a history or abuse were associated with higher odds for elevated depressive symptoms. However, RD was associated with higher odds of elevated depressive symptoms only among those with the s allele, but engagement in avoidance-based coping was associated with higher odds for elevated depressive symptoms among the ll-genotype. Table 2 Multivariable hierarchical logistic regression predicting level of depressive symptoms. Table 3 Multivariable logistic regressions predicting level of depressive symptoms, separately for each 5-HTTLPR group. An additional follow-up test was conducted to further examine the proposed differential susceptibility hypothesis, whereby those with the s allele are more sensitive toward and responsive to their environment. A layered Chi-Square test was conducted, with separate Chi-Square tests run by 5-HTTLPR group (s allele group and the ll allele group) to determine the association between level of RD (low vs.