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Hsia et al. (21) directly evaluated the algorithm in 161,808 women 50 to 79 years of age who were enrolled in the Women's Health Initiative and followed up for a mean of 7.8 years. When the 2007 update categories were applied, 11% of women were found to be at high risk, 72% were at risk, and 4% were at optimal risk (21). Of note, 13% of women could not be classified by the 2007 algorithm because, although they lacked risk factors, they did not adhere to a healthy lifestyle. Among high-risk, at-risk, optimal risk, and unclassified women, the rates of MI, CHD death, or stroke were 19.0%, 5.5%, 2.2%, and 2.6% per 10 years, respectively (p for trend Venetoclax ic50 of different race/ethnic groups, the 2007 risk classification algorithm appropriately ordered event selleck kinase inhibitor rates in all groups, with a 7- to 20-fold difference in event rates between optimal-risk and high-risk women. The 2007 update algorithm discriminated those who experienced coronary events with accuracy similar to current National Cholesterol Education Panel Adult Treatment Panel III risk categories (20%) based on Framingham 10-year predicted risks (20). Therefore, the current panel elected to continue this general approach to risk classification in women for the 2011 guidelines with some modifications (Table 2). First, the AHA recently defined a new concept of ��ideal cardiovascular health�� defined by the absence of clinical CVD and the presence of all ideal levels of total cholesterol (SB431542 pressure (