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05. Results In both studies, all subjects completed all 3 study visits, and the study conditions were well tolerated, with no subject experiencing adverse effects. All data are from all subjects (n = 10), with the exception of basal pyloric pressures in study A (L-Phe), for which data analysis was not possible in 2 subjects, due to technical problems. Study A: Effects of L-phenylalanine Antropyloroduodenal pressures Baseline values for antral, duodenal and pyloric pressures did not differ among study days (data not shown). Antral pressures. There was an effect of treatment on the mean amplitude (P BIBW2992 reduced the amplitude, and L-Phe 0.45, but not L-Phe 0.15, reduced the MI, of antral PWs compared with control. Table 1. Effects of Intraduodenal Infusions of L-Phenylalanine (Study A) or L-Glutamine (Study B), Each at Loads of 0.15 kcal/min or 0.45 kcal/min, or Saline Control, Each for 90 Minutes at a Rate of 4 mL/min, on Antral and Duodenal Pressures Basal pyloric pressure. There was no effect of treatment on BPP (Fig. 2A). Figure 2. Basal pyloric pressure (BPP) (A, D), and number (B, E), and amplitude (C, F) of isolated pyloric pressure waves (IPPWs) during 90-minute intraduodenal (ID) infusions of L-phenylalanine (L-Phe; A, B, C), or L-glutamine (L-Gln; D, E, F), at (1) 0.15 kcal/min ... Isolated pyloric pressure. There was an effect of treatment on the number (P NVP-BKM120 cell line (Fig. 2B), but not the amplitude (Fig. 2C), of IPPWs. The mean number of IPPWs was higher during L-Phe 0.45, but not L-Phe 0.15, compared with control, however, post-hoc comparisons revealed no significant differences between treatments. Duodenal pressures. There was no effect of treatment on the total number, mean amplitude, or the MI, of duodenal PWs (Table 1). Plasma cholecystokinin concentrations Baseline plasma concentrations did not differ among study days. There was a treatment �� time interaction (P SWAP70 L-Phe 0.45 increased plasma CCK promptly at 15 minutes, and the effect was sustained until t = 90 minutes compared with control. L-Phe 0.15 increased plasma CCK at 15�C30 minutes and at 60 minutes and 90 minutes compared with control. Figure 3. Plasma cholecystokinin (CCK) during 90-minute intraduodenal (ID) infusions of L-phenylalanine (L-Phe; A), or L-glutamine (L-Gln; B), at (1) 0.15 kcal/min (L-Phe 0.15 or L-Gln 0.15), or (2) 0.45 kcal/min (L-Phe 0.45 or L-Gln 0.45), or saline control. Repeated-measures ... Correlations between the load of L-phenylalanine, antropyloroduodenal motility, and plasma cholecystokinin There was a negative correlation between the dose of L-Phe and the total number (r = ?0.50, P