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Another important direction for future research will be to understand whether and how both partners' hormones and changes in hormones are associated with postpartum behavior and adjustment. The authors are grateful to the couples who participated in our research and to the many research assistants who assisted with data collection, including Meg Boyer, Rebecca Hoen, Emily Lukasik, Chelsey Weiss, and Maeve Zolkowski. ""2537" "There is convincing evidence that inflammation plays a pivotal role in the pathophysiology of complex regional pain syndrome (CRPS). Besides inflammation, central sensitization is also an important phenomenon. Mast cells are known to be involved in the inflammatory process of CRPS and also play a role (at least partially) in the process of central sensitization. In the development of a more mechanism-based treatment, influencing the activity DNA Methyltransferas inhibitor of mast cells might be important in the treatment of CRPS. We describe the rationale for using medication that counteracts the effects of mast cells in the treatment of CRPS. ""2538" "Chronic PD98059 cost low back pain (cLBP) patients who take at least 1 CYP450-metabolized opioid analgesic agent concurrent with at least 1 other CYP450-metabolized medication experience a drug�Cdrug exposure (DDE), which puts them at risk for a pharmacokinetic drug�Cdrug interaction (PK DDI). This study compared utilization of healthcare resources and associated payments in cLBP patients with and without incident DDEs with the potential to cause PK DDIs. A retrospective database analysis examined the associated clinical events, healthcare utilization (measured in terms of claims for office visits, outpatient visits, emergency Tryptophan synthase department visits, and hospitalization), and cost to the health plan, as defined as the sum of health plan payments for resources used. Patients were grouped into 2 cohorts by age (those under 65 and those 65?years and over). In the 6?months after exposure, total healthcare payments were significantly higher for DDE patients than those without DDEs (no-DDE), in both in the younger ($7,086, SD?=?$8,370) and $6,353, SD?=?$8,352, respectively, P?