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Results The descriptive statistics of the different variables evaluated in both groups are shown in Table ?Table11 Table 1 Mean scores and standard deviations of the two groups (control and experimental group) for the different tests used in both phases of the study. Four MANOVAs 2 (group: experimental vs. control) �� 2 (sex: males vs. females) �� 2 (time: pretest vs. posttest) were run, respectively on EFAI-E, EFAI-N, Raven, CSAQ-a, with the first two factors between-subjects and the last within-subjects, and using the Greenhouse-Geisser correction (the most conservative). In order to contrast hypotheses 1 and 2, the spatial ability results (EFAI-E) revealed a significant main effect due to time factor, F(1, 41) = 90.09, RMS = 441.98, p Selleckchem Ruxolitinib and an interaction between time �� group, F (1, 41) = 4.82, RMS = 23.65, p click here emerged on EFAI-N, Raven, CSAQ-a. A statistically significant improvement was observed for the EG after the intervention in spatial ability (EFAI-E), t (20) = 8.95, p (23) = 5.12, p meprobamate hypothesis of the study. In the EG, no significant sex differences were found for the increases in spatial ability (EFAI-E), t (19) = 0.12, p = 0.91 [boys: M = 5.55, SD = 3.11; girls: M = 5.40, SD = 2.59]. Furthermore, in order to contrast hypothesis 3, an ANCOVA 2 (groups) �� 2 (sex) was performed for the EFAI-E scores of the pretest phase, considering previous experience with videogames as a covariate. No significant differences were found between groups, or between sexes and no significant differences were found for experience with videogames. The same ANCOVA was performed for the EFAI-E scores after training, not finding any significant differences. For the total sample, no significant differences were obtained between sexes for the experience with video games (VEPQ), t (43) = 0.12, p = 0.90 [boys: M = 3.87, SD = 1.42; girls: M = 3.82, SD = 1.37]. Regarding the contrast of hypotheses 4 and 5, in the pretest phase for the total sample, a significant positive correlation between experience with video games and spatial ability (r = 0.30, p