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Carriers of this homozygous deletion show a significantly higher score in the alcohol dependence severity (P?AZ191 the association between the homozygous deletions and alcohol dependence severity. Interestingly, the precuneus is not only anatomically and functionally connected to the ACC and thalamus (the main active regions to the alcohol cue), but also has the most predictive power to the alcohol dependence severity. These findings suggest that the homozygous deletion at 22q13.1 may have an important impact on the function of the precuneus with downstream implications for alcohol dependence. ""There is growing evidence that physician health programs (PHPs) are an important component in physicians�� recovery from substance disorders, although we do not know how variations in treatment and monitoring affect physician recovery. This study was designed to understand how programmatic differences impact clients�� overall program completion. This study was part of a larger INCB018424 investigation, the Blueprint Project, which evaluated outcomes for clients enrolled in PHPs nationally. Here we compared physicians presenting to a Colorado-based PHP for substance use to a nationally based referent, contrasting treatment, monitoring, and outcomes (Colorado n = 72, National n = 730). The samples were similar demographically although more Colorado physicians were polysubstance users. We found variations in treatment and monitoring patterns with Colorado physicians participating in more types of primary treatment and monitoring services and were allowed to work more at some point during monitoring. There was greater relapse among Colorado physicians, but these differences disappeared when we controlled for prior treatment. The great majority of clients in both samples showed successful recovery. buy PF-02341066 This data provides a foundation on which to understand population characteristics, contractual differences, and outcome variations among PHPs and serves to inform internal PHP programmatic structures and regulatory agencies. (Am J Addict 2012;00:1�C8) ""Until a decade ago, a range of methodological, cultural, attitudinal and legal barriers meant that we had few or no data on patterns of cannabis use from community settings [1,2]. Views on the harms around cannabis use were generally personalized, polarized and of little use in guiding policy [3]. Prospective studies outside the clinic have now led to very different understandings of cannabis use and its consequences [4]. Despite this remarkable progress, Temple and colleagues suggest that we have already hit a ��grass ceiling��[5]. They argue that current conceptualization and measurement of cannabis use are major barriers to progress. It is true that community studies typically employ frequency or dependency to define use (e.g. [6�C8]).