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Data were abstracted using a standardized protocol and a meta-analysis was performed. 3. Five studies of a total 1789 patients with CAD Adenosine qualified for analysis. Administration of high-dose statins in CAD patients before PCI was associated with a significant reduction in MACE 30?days after the procedure. The incidence of MACE in the high-dose statin group (6.98%) was significantly lower than that in the placebo group (14.77%), with an odds ratio (OR) of 0.43 (95% confidence interval (CI) 0.31�C0.59; P?selleck kinase inhibitor anaesthetized Tanespimycin concentration and ventilated dogs were divided into the following two groups: the ��aortic volume group�� (n= 5), in which aortic and IVC (inferior vena caval) dimensions were measured ultrasonically; and the ��reservoir volume group��, in which aortic and IVC reservoir volumes were calculated using the reservoir�Cwave model. Measurements were made in control conditions, in the presence of nitroprusside and methoxamine and after volume loading. In both the aortic volume group and the reservoir volume group, the maximal rate of increase in ��Z[(dZ/dt)max] strongly correlated with the maximal rate of change in aortic/reservoir blood volume (R2= 0.85 and 0.95, respectively), which in turn was proportional to the LV SV. The LV and IVC contributions to ��Z were small in control conditions (?5 and 1%, respectively), but the LV contribution increased slightly (to 7%) with administration of methoxamine and after volume loading (to 10%). It is concluded that the change in thoracic impedance (��Z) during the cardiac cycle is proportional to the change in aortic reservoir (i.e. Windkessel) volume, which provides a mechanistic explanation for previously demonstrated good correlations with standard measures of cardiac output.