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Overgrowth is not exclusively a bacterial domain. Among the panoply of such microorganisms, some are recognizable as pathogens; however, others that at the beginning may behave as commensal or seem to be of low risk status, have subsequently been shown to cause disease. Mulligan et al. (1982) revealed that cefoperazone PDGFRB induced severe changes in fecal flora, such as suppression of Enterobacteriaceae, and increase in counts of Candida sp. A study involving a group of persons treated with parental ceftriaxone also showed an overgrowth of yeasts in stools; in patients treated with cefotaxime, Candida sp. was also recovered from throat swabs (Devrieshospers et al., 1991). Pecquet et al. (1987) described a situation of five healthy adults receiving oral ofloxacin during 5 days (Pecquet et al., 1987); ofloxacin induced selective elimination of aerobic Gram-negative bacteria. During treatment, colonization of all the volunteers by Candida sp. was detected. The effect of amoxicillin on the ecology of skin microbial flora was also investigated; it revealed a decrease in the number of bacterial isolates and an increase in C. albicans. Samonis et al. (1994), revealed that amoxillin-clavulanate induced a higher and more persistent gastrointestinal colonization by yeasts comparatively to other tested antibiotics (Samonis et al., 1994). The effect of amoxicillin therapy on the ecology of skin microbial flora in infants was also investigated; it revealed a decrease in the number of bacterial isolates and increase in C. albicans recovery (Brook, 2000). Among ICU patients infections by Candida sp. are of very high prevalence. A study performed by Charles et al. (2005), demonstrated that broad-spectrum antibiotic therapy was found to promote fungal growth in patients with prior yeast colonization (Charles et al., 2005). The authors recommended the reduction of antibiotic therapy for prevention of fungal infections in this particular case, since most cases of invasive candidosis in ICU setting are supposed to be subsequent to colonization in high-risk patients. A study involving ICU patients in Ankara Training and Research Hospital, Turkey, showed that Candida colonization emerged more often in patients with bacterial sepsis and in those exposed to broad spectrum antibiotics (Ergin et al., 2013). A study concerning fungaemia in a portuguese university hospital, revealed that 93% of the patients had received antibacterial drugs and in 68% of the cases, a combination of two or more antibacterial drugs had been administered simultaneously (Costa-de-Oliveira et al., 2008). Another study involving antibiotic treated and untreated Syrian hamsters inoculated intragastrically with C.