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2.2. Data Collection and Outcome Measures We collected patient demographics at enrollment. Medicosociohistory included smoking history, psychiatric history, alcohol intake, education level, modified early warning score (MEWS), and acute physiological and chronic health evaluation FLT3 inhibitor (APACHE). Clinical characteristics included organ dysfunction, surgical status, comorbidities, and biochemical and haematological values. Treatment characteristics included sedation drugs, use of restraints, endotracheal intubation, mode of ventilation, chest X-ray findings, and route of administration of feeds. Primary outcome was presence of delirium. Secondary outcomes were death and length of ICU stay. 2.3. Ethical Considerations The study was approved by the Research and Ethics Committee of the School of Medicine, College of Health Sciences, Makerere University, as well as the Uganda National Council MK8776 of Science and Technology according to the ethical standards laid down in the 1964 Declaration of Helsinki and its later amendments. All study participants or their next of kin gave informed consent to participate in the study. 2.4. Statistical Analysis To be able to detect with 95% power a 10% difference in incidence in our hospitals from the previously reported incidence in hospitalized patients who required mechanical ventilation [1], a sample size of 160 was required. All data were analyzed using STATA (StataCorp. 2011. Stata Statistical Software: Release 12. College Station, TX: StataCorp LP). Categorical data has been presented as percentages and continuous data as means with standard deviations. Comparisons were made between participants who developed delirium and those who did not. For the categorical variables, Pearson ��2 tests or Fisher's exact test was used. For the continuous data, Student's t-test or Wilcoxon rank sum test was used for the normally and skewed data, respectively. Unadjusted logistic models were used to examine the effect of various factors independently on delirium presence (age, gender, admission diagnosis, history Thymidine kinase of mental illness, history of alcohol intake, length of ICU stay, use of restraints, type of airway, sedation schedule, drugs, and metabolic abnormalities). Variables with P