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The Wilcoxon signed rank or the Mann�CWhitney tests were used to compare differences between two paired selleck compound or unmatched groups. A P value of A total of 195 patients were included in the study at 85 participating centres in Germany. All patients attended the control visit after 16 weeks, and 173 (88.7%) patients were followed-up for a period of 6 months. Patients' characteristics and baseline data are summarised in Table?2. All patients were atopic, showing allergies against house dust mite (81%), animal dander (58.5%), moulds (46.2%), grass (61.5%) or birch (64.6%). The asthma was concomitant by allergic rhinitis (n?=?131, 72.4%), atopic eczema (n?=?47, 26.0%), urticaria (n?=?25, 13.8%) and other disorders (n?=?18, 9.9%). The absolute values of FEV1 as well as the % predicted were found to be improved in patients after a 16-week treatment period. FEV1[mean?��?standard deviation (SD)] increased from 2.05?L?��?0.77?L to 2.31?L?��? 0.84?L, or 63.6%?��?18.3% to 73.7%?��?20.3%, representing a total difference of 270?mL, or an increase of 10.1% predicted, respectively that was statistically significant; P?ATPase (P?MG-132 ic50 work/school days could significantly (P? reduced from 6.21?��?8.08 (mean?��?SD) to 0.49?��?1.34 following 16 weeks of treatment with OMA (Fig.?4A). Although treatment responders had significantly more days of absence at baseline compared with non-responders (7.12 vs 2.65, P?