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The more increased degree of head-up, the more decreased R5 and Veliparib in vitro R20 (ANOVA: p?Temozolomide patients with unexplained dyspnea. Methods?Retrospective analysis of patients undergoing CPETwith stationary cycle ergometer for unexplained dyspnea during January 2010-December 2011 at the Singapore General Hospital. Results reported by three consultants independently and consensus reached. The outcomes of the patients and significant investigations, over the next 2 year period were reviewed. Results?Out of 62 subjects who underwent CPET,32 patients with maximal exercise test were analysed. Of those 32 subjects, mean work rate was 119.22(35�C210), mean Vo2 max was 22.5?ml/kg/min (9.5�C37.8). 6 subjects (18%) had normal exercise tests. None had health care visits related to dyspnea over 2 years.19 subjects (59%) had cardiac limitation or deconditioning with mean Vo2 max 20.9?ml/kg/min (11.36�C28.88), mean anaerobic threshold 28.58% (17�C48), and mean O2/HR of 8.74(5�C13).5 subjects had no cardiac evaluation.13 subjects had cardiac evaluation with DDR1 two abnormal findings (one ischaemia and one heart failure). Seven subjects (22%) had deconditioning with mean Vo2 max 25.9?ml/kg/min (9.55�C32), mean and Anaerobic threshold 34.5% (27�C46). One subject had normal cardiac evaluation. None had health care visits related to their dyspnea over the 2 years. In our study, among those with maximal exercise testing, 2 subjects with normal study group had cardiac evaluation, 1 with cardiac limitation group had CT thorax revealing TB and 1 in the deconditioning group had coronary angiogram. The remaining 87% (28/32) either had targeted investigations pertaining to the limitation or did not undergo any investigation with 2 year stability. Conclusion?CPET is a useful tool to channel out subsequent evaluation for dyspnea in a focused manner thereby limiting the amount of investigations that have to be undergone otherwise in the outpatient setting. ""3885" "Colorectal cancer is one of the most common cancer types worldwide and accounts for approximately 600,000 deaths annually. Work over the last decades has uncovered a number of tumor-suppressor and oncogenes which are frequently mutated and might thus be responsible for the malignant transformation.