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An overall mean SAS was also calculated as the average of the three standardized scores. SAS were calculated by comparing an adolescent��s raw score with the national standardization sample score adjusted for age and were calculated by an external organization (GL Assessment, London). The decision to use participants�� SAS rather than raw scores as outcomes was based on several factors. First, SAS allow for performance to be compared to the general population to place a pupil��s performance on a meaningful scale. Second, SAS are adjusted to take account of a pupil��s age at the time the test was taken. SAR405838 molecular weight Third, SAS are comparable across CAT levels and therefore allowed the maximum number of cases to be included in the analysis. Finally, SAS are comparable across batteries to permit comparisons between the three domains assessed. Ethical considerations Ethical approval was obtained from the School of Psychology Research Ethics Committee at the University of Leeds, UK. This study adopted a process of assent to determine whether potential participants and their parents/guardians were willing to take part in the study. A letter was sent home to the parents/guardians LEE011 datasheet of the participating school pupils, containing a cover letter and information sheet for the parent/guardian and an information sheet for the adolescent participants who were all aged 11�C13?years. These letters provided parents and potential participants with written information about the purpose of the study and requirements for participation. These documents also stated that parents/participants should contact the researchers, via email or telephone, with any questions or queries regarding the study. Parents/guardians were informed that if they were happy for their child to take part in the study they did not need to respond to the letter or notify the researchers, and consent (by a process of assent) Resiquimod was assumed. Alternatively, if parents/guardians were not happy for their child to participate in the study, they were requested to return a reply slip that was enclosed with the letter. Statistical analysis Statistical analyses were performed using SPSS version 21 (SPSS, Inc., Chicago, IL, USA) and the significance level (��-level) was set as p?