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Using the full Selleck Everolimus cohort of 853 participants and mothers breastfeeding for more than 6?months as a reference group, children who had not been breastfed were not at an increased risk of suffering from AD, asthma or to be sensitized (Table S2). However, a maternal history of allergic diseases significantly modified the association between breastfeeding duration and asthma at age 6?years (P for interaction?=?0.021), increasing the odds for asthma among children with a positive maternal history with increasing duration of breastfeeding (aOR for the interquartile range of duration of breastfeeding; 95% CI: 2.34; 1.05�C5.21). Results were similar when the analyses were based on exclusive instead of any breastfeeding. Transforming growth factor-��1 levels in breast milk measured at the age of 2?months were significantly higher in Finnish mothers, smokers and those who were breastfeeding for a shorter duration (P-value for adjusted linear trend Cilengitide to one or two species of farm animals (aOR 95% CI: 1.10 [1.01�C1.20]) during pregnancy. Contact to cats during pregnancy was associated with higher levels of breast milk sIgA in both crude and mutually adjusted models (aOR 95% CI: 1.10 [1.01�C1.19] and 1.01 [1.01�C1.20], respectively). After mutual adjustment, sIgA levels also remained inversely associated with duration of breastfeeding (P-value for adjusted linear trend click here more than one child. Farming was not significantly associated with sIgA or TGF-��1 levels (Table?2). Soluble IgA and TGF-��1 levels in breast milk were moderately, but significantly correlated (Pearson's coefficient: 0.44, P?