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This group had also significantly higher CSF albumin (p?GSK126 solubility dmso in age distribution were found among all groups, except when group?B was compared Transducin with group?C. Higher age was associated with longer duration of symptoms. The acute-phase symptoms are presented in Table?3. The only laboratory parameter in the acute phase that differed significantly among the groups was Borrelia-specific CSF IgG, which was highest in group?D. No significant differences were found among the groups regarding type of antibiotic treatment or duration of treatment. The total healthcare cost for the patients in the study group was estimated to be ��500?000. The number of visits to a physician in an outpatient department was 490, the cost of which was estimated to be ��130?000. The number of outpatient visits per individual varied between 0 and 10 (median, 3), and 79 patients (53%) were hospitalized (median, 5?days; range, 1�C60?days). The total number of days in hospital for the entire study group was 603. Diagnosis-related group weights varied from 0.3104 to 1.8067 (median, 0.7825). The estimated total cost of hospital care was ��330?000, i.e. ��4200 per patient. (For selleckchem comparison, the estimated costs of hospital care were ��2800 per patient for pneumonia, ��2300 per patient for viral meningitis, and ��5200 per patient for sepsis). Children under 8?years of age were often treated with ceftriaxone administered intravenously once daily by a nurse in primary healthcare. In this study, 509 ceftriaxone days were registered, resulting in an estimated cost of ��38?000. Of the adult patients aged 16�C64?years, 26 (51%) received sickness benefits from the Social Insurance Agency (range, 4�C528?days; median, 32?days). The mean cost of sickness benefits was ��4600 per patient. Temporary parental benefits were granted to the parents of 39 (51%) of the children (range, 0.25�C19?days; median, 5?days). The estimated total cost of social benefits was ��134?000 (��2000 per patient). The number of NB cases verified by CSF analysis increased from 5/100?000 to 10/100?000 inhabitants/year during the years 2000�C2005 in J?nk?ping County. The number of NB cases during the first part of the study period was 5�C6/100?000 inhabitants, which is approximately half as many as reported previously [1].